Evaluating the efficacy of breast cancer treatments using PET-CT Imaging

Authors

  • Muntaser S. Ahmad Faculty of Allied Medical Health, Palestine Ahliya University and Department of Nuclear medicine, Al-Ahli Hospital (Palestine).
  • Qais Hjouj Faculty of Medicine, Al-Quds University (Palestine)
  • Majed Alshareef Faculty of College of Pharmacy & Medical Science, Hebron University (Palestine).
  • Miral Asfour Faculty of College of Pharmacy & Medical Science, Hebron University (Palestine).
  • Ashraf Sqeer Faculty of College of Pharmacy & Medical Science, Hebron University (Palestine).
  • Mohammad Qwasmeh Faculty of College of Pharmacy & Medical Science, Hebron University (Palestine).
  • Mohammad Hjouj Faculty of Health Professions, Al-Quds University (Palestine)

DOI:

https://doi.org/10.59994/pau.2023.1.158

Abstract

Positron emission tomography-computed tomography (PET-CT) scans are used to detect and stage cancer and can be used to evaluate the effectiveness of treatments used for patients with different types of cancer. The current study aims to evaluate the effectiveness of treatments provided to breast cancer patients and the effect of treatment on the right and left breasts separately. A sample of (84) female left and right breast cancer patients were treated with radiation therapy and/or chemotherapy. The efficacy of the treatments was evaluated on 18 follow-up patients among the original sample who already underwent a PET-CT scan before starting their treatment. Treatment efficacy was evaluated by measuring the standard uptake value (SUV) of cancer lesions in patients before and after treatment.   Results showed that 32.1% of the diagnosed lesions did not change their SUV values, 39.3% were treated, 27.4% were new lesions do not present in the original PET-CT scan, and 1.2% for lesions that increased the value of the SUV. Moreover, the results also showed that left breast cancer was more responsive to treatment than right breast cancer, while chemotherapy was more effective than radiation therapy. In summary, the efficacy of chemotherapy and/or radiotherapy for both right and left breast cancer patients was evaluated using PET-CT technology. Only one-third of the cancerous lesions were treated using the treatment methods described in this study. The research is unique in that it is the first in Palestine to investigate the feasibility and efficacy of the treatment delivered to breast cancer patients.

Keywords:

PET-CT, Breast Cancer, Chemotherapy, Radiation therapy

References

Ahmad, M. S., & Arab, A. (2022). Ability of MRI Diagnostic Value to Detect the Evidence of Physiotherapy Outcome Measurements in Dealing with Calf Muscles Tearing. Journal of Medical – Clinical Research & Reviews, 6(10), 6–11. https://doi.org/10.33425/2639-944X.1292

Ahmad, M. S., Makhamrah, O., & Hjouj, M. (2021a). Multimodal Imaging of Hepatocellular Carcinoma Using Dynamic Liver Phantom. Intechopen, tourism, 13.

https://doi.org/https://doi.org/10.1016/j.radphyschem.2021.109632

Ahmad, M. S., Makhamrah, O., Suardi, N., Shukri, A., Ashikin Nik Ab Razak, N. N., Oglat, A. A., & Mohammad, H. (2021b). Hepatocellular carcinoma liver dynamic phantom for MRI. MR Imaging of the Internal Auditory Canal and Inner Ear at 3T: Comparison between 3D Driven Equilibrium and 3D Balanced Fast Field Echo Sequences, 188, 109632.

https://doi.org/10.1016/j.radphyschem.2021.109632

Ahmad, M. S., Makhamrah, O., Suardi, N., Shukri, A., Suardi, N., Noor, Nik Nik, A., & Hjouj, M. (2021c). Agarose and Wax Tissue-Mimicking Phantom for Dynamic Magnetic Resonance Imaging of the Liver. Journal of Medical - Clinical Research & Reviews, 5(11), 1-11.

https://doi.org/10.33425/2639-944X.1250

Ahmad, M. S., Rjoub, B., Abuelsamen, A., & Mohammad, H. (2022). Evaluation of Advanced Medical Imaging Services at Government Hospitals-West Bank. Journal of Medical - Clinical Research & Reviews, 6(7), 1–7. https://doi.org/10.33425/2639-944X.1280

Ahmad, M. S., Suardi, N., Shukri, A., Mohammad, H., Oglat, A. A., Abu, B. M., Mohamed, A. M. H., & Makhamrah, O. (2019). Current Status Regarding Tumour Progression, Surveillance, Diagnosis, Staging, and Treatment Of HCC A Literature Review. Journal of Gastroenterology and Hepatology Research, 8(2), 2841–2852.

Ahmad, M. S., Suardi, N., Shukri, A., Nik Ab Razak, N. N. A., Oglat, A. A., Makhamrah, O., & Mohammad, H. (2020a). Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality Imaging. European Journal of Radiology Open, 7, 100257.

https://doi.org/10.1016/j.ejro.2020.100257

Ahmad, M., Shareef, M., Wattad, M., Alabdullah, N., D. Abushkadim, M., & A. Oglat, A. (2020b). Evaluation of Exposure Index Values for Conventional Radiology Examinations: Retrospective Study in Governmental Hospitals at West Bank, Palestine. Atlas Journal of Biology, 724–729. https://doi.org/10.5147/ajb.vi.219

Ahmad, M., Suardi, N., Shukri, A., Mohammad, H., Oglat, A., Alarab, A., & Makhamrah, O. (2020c). Chemical characteristics, motivation and strategies in choice of materials used as liver phantom: A literature review. Journal of Medical Ultrasound, 28(1), 115–117.

https://doi.org/10.4103/JMU.JMU_4_19

Ahmad, M., Suardi, N., Shukri, A., Noor Ashikin Nik Ab Razak, N., A. Oglat, A., Makhamrah, O., & Mohammad, H. (2020d). A Recent Short Review in Non-Invasive Magnetic Resonance Imaging on Assessment of HCC Stages: MRI Findings and Pathological Diagnosis. Journal of Gastroenterology and Hepatology Research, 9(2), 3113–3123.

https://doi.org/10.17554/j.issn.2224-3992.2020.09.881

Al-Tell, A. (2019). Justification of Urgent Brain CT Examinations at Medium Size Hospital, Jerusalem. Atlas Journal of Biology, 655–660. https://doi.org/10.5147/ajb.v0i0.213

Avril, S., Muzic, R. F., Plecha, D., Traughber, B. J., Vinayak, S., & Avril, N. (2016). 18 F-FDG PET/CT for Monitoring of Treatment Response in Breast Cancer. Journal of Nuclear Medicine, 57(Supplement 1), 34S-39S. https://doi.org/10.2967/jnumed.115.157875

Ban, C. C., Khalaf, M. A., Ramli, M., Ahmed, N. M., Ahmad, M. S., Ahmed Ali, A. M., Dawood, E. T., & Ameri, F. (2021). Modern heavyweight concrete shielding: Principles, industrial applications and future challenges; review. Journal of Building Engineering, 39(December 2020), 102290. https://doi.org/10.1016/j.jobe.2021.102290

Bohnert, A. S. B., Guy, G. P., & Losby, J. L. (2018). Opioid Prescribing in the United States Before and After the Centers for Disease Control and Prevention’s 2016 Opioid Guideline. Annals of Internal Medicine, 169(6), 367. https://doi.org/10.7326/M18-1243

Brownlee, Z., Garg, R., Listo, M., Zavitsanos, P., Wazer, D. E., & Huber, K. E. (2018). Late complications of radiation therapy for breast cancer: evolution in techniques and risk over time. Gland Surgery, 7(4), 371–378. https://doi.org/10.21037/gs.2018.01.05

Han, S., & Choi, J. Y. (2020). Prognostic value of 18F-FDG PET and PET/CT for assessment of treatment response to neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis. Breast Cancer Research, 22(1), 1–15. https://doi.org/10.1186/s13058-020-01350-2

Hennessey, S., Huszti, E., Gunasekura, A., Salleh, A., Martin, L., Minkin, S., Chavez, S., & Boyd, N. F. (2014). Bilateral symmetry of breast tissue composition by magnetic resonance in young women and adults. Cancer Causes & Control, 25(4), 491–497.

https://doi.org/10.1007/s10552-014-0351-0

Hudson, S. M., Wilkinson, L. S., Denholm, R., De Stavola, B. L., & Dos-Santos-Silva, I. (2020). Ethnic and age differences in right-left breast asymmetry in a large population-based screening population. The British Journal of Radiology, 93(1105), 20190328.

https://doi.org/10.1259/bjr.20190328

Kmail, M., S. Ahmad, M., & Hjouj, M. (2022). Evaluating the Accuracy of 128-Section Multi-Detector Computed Tomography (MDCT) in Detecting Coronary Artery Stenosis. Proceedings of the 2022 5th International Conference on Digital Medicine and Image Processing, 58–62. https://doi.org/10.1145/3576938.3576948

Knudsen, K. E., Wiatrek, D. E., Greenwald, J., McComb, K., & Sharpe, K. (2022). The American Cancer Society and patient navigation: Past and future perspectives. Cancer, 128(S13), 2673–2677. https://doi.org/10.1002/cncr.34206

Lubejko, B. G., & Wilson, B. J. (2019). Oncology nursing: Scope and standards of practice. Oncology Nursing Society.‏

Makhamrah, O., Ahmad, M. S., & Hjouj, M. (2019). Evaluation of Liver Phantom for Testing of the Detectability Multimodal for Hepatocellular Carcinoma. Proceedings of the 2019 2nd International Conference on Digital Medicine and Image Processing, 17–21.

https://doi.org/10.1145/3379299.3379307

Makhamrah, O., Ahmad, M. S., Doufish, D., & Mohammad, H. (2023). Internal Auditory Canal (IAC) and Cerebellopontine Angle (CPA): Comparison between T2-weighted SPACE and 3D-CISS sequences at 1.5T. Radiation Physics and Chemistry, 206, 110797.

https://doi.org/10.1016/j.radphyschem.2023.110797

Mohammad, M., Ms, A., Mudalal, M., Bakry, A., & Arzeqat, T. (2020). The Radioactive Iodine (I-131) Efficiency for the Treatment of Well-Differentiated Thyroid Cancer. HSOA Journal of Nuclear Medicine, Radiology& Radiation Therapy, 5(25), 5–10.

https://doi.org/10.24966/NMRR-7419/100025

Muntaser S Ahmad, Zeyadeh, S. L., Odah, R., & Oglat, A. (2019). Occupational Radiation Dose for Medical Workers atAl-Ahli Hospital in West Bank-Palestine. Journal of Nuclearmedicine, Radiology & Radiation Therapy, 5(17), 1259–1266.

https://doi.org/10.1016/j.jtusci.2017.01.003

Oglat, A. A., Alshipli, M., Sayah, M. A., & Ahmad, M. S. (2020). Artifacts in Diagnostic Ultrasonography. Journal for Vascular Ultrasound, 44(4), 212–219.

https://doi.org/10.1177/1544316720923937

Oglat, A., Matjafri, M., Suardi, N., Oqlat, M., Abdelrahman, M., Oqlat, A., Farhat, O., Alkhateb, B., Abdalrheem, R., Ahmad, M., & Abujazar, M. M. (2018a). Chemical items used for preparing tissue-mimicking material of wall-less flow phantom for doppler ultrasound imaging. Journal of Medical Ultrasound, 26(3), 123-127. https://doi.org/10.4103/JMU.JMU_13_17

Oglat, A., Matjafri, M., Suardi, N., Oqlat, M., Abdelrahman, M., Oqlat, A., Farhat, O., Alkhateb, B., Abdalrheem, R., Ahmad, M., & Abujazar, M. M. (2018b). Chemical items used for preparing tissue-mimicking material of wall-less flow phantom for doppler ultrasound imaging. Journal of Medical Ultrasound, 26(3), 123. https://doi.org/10.4103/JMU.JMU_13_17

Paydary, K., Seraj, S. M., Zadeh, M. Z., Emamzadehfard, S., Shamchi, S. P., Gholami, S., Werner, T. J., & Alavi, A. (2019). The Evolving Role of FDG-PET/CT in the Diagnosis, Staging, and Treatment of Breast Cancer. Molecular Imaging and Biology, 21(1), 1–10.

https://doi.org/10.1007/s11307-018-1181-3

Schoemaker, M. J., Nichols, H. B., Wright, L. B., Brook, M. N., Jones, M. E., O’Brien, K. M., Adami, H.-O., Baglietto, L., Bernstein, L., Bertrand, K. A., Boutron-Ruault, M.-C., Braaten, T., Chen, Y., Connor, A. E., Dorronsoro, M., Dossus, L., Eliassen, A. H., Giles, G. G., Hankinson, S. E., … Swerdlow, A. J. (2018). Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women. JAMA Oncology, 4(11), e181771.

https://doi.org/10.1001/jamaoncol.2018.1771

Waks, A. G., & Winer, E. P. (2019a). Breast Cancer Treatment. JAMA, 321(3), 316. https://doi.org/10.1001/jama.2018.20751

Waks, A. G., & Winer, E. P. (2019b). Breast Cancer Treatment. JAMA, 321(3), 288. https://doi.org/10.1001/jama.2018.19323

Wang, L. (2017). Early Diagnosis of Breast Cancer. Sensors, 17(7), 1572. https://doi.org/10.3390/s17071572

Downloads

  • PDF

Published

2023-04-01

How to Cite

S. Ahmad, M., Hjouj, Q., Alshareef, M., Asfour, M., Sqeer, A., Qwasmeh, M., & Hjouj, M. (2023). Evaluating the efficacy of breast cancer treatments using PET-CT Imaging . Journal of Palestine Ahliya University for Research and Studies, 2(1), 158–170. https://doi.org/10.59994/pau.2023.1.158

Issue

Vol. 2 No. 1 (2023)

Section

Articles

License

Copyright (c) 2023 Journal of Palestine Ahliya University for Research and Studies

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.