Performance Metrics Comparison of CT with PET/CT Reports in Lymphoma Patient Follow-Up
DOI:
https://doi.org/10.59994/ajamts.2024.1.36Abstract
The incidence of Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL) is rising annually, necessitating effective monitoring strategies. Computed Tomography (CT) and Positron Emission Tomography/Computed Tomography (PET/CT) are pivotal in this regard but differ in diagnostic accuracy due to their distinct imaging capabilities. This retrospective study evaluates 56 lymphoma patients using both modalities at Al-Ahli Hospital, Hebron, Palestine, from 2020 to 2023. Demographic and clinical data, alongside imaging findings, were analyzed. Results indicate PET/CT's superiority over CT alone, with higher sensitivity, specificity, precision, Accuracy where CT findings were 20%, 30.61%, 0.72%, and 30.34% retrospectively compared with PET/CT findings. Gender-specific analysis revealed marginal associations, highlighting the need for tailored imaging strategies. The study underscores PET/CT's enhanced diagnostic performance in lymphoma surveillance, advocating its use for improved patient management and outcomes. Further research could refine these findings, addressing the evolving landscape of lymphoma imaging.
Keywords:
Computed Tomography, Positron Emission Tomography/Computed Tomography, Hodgkin’s Lymphoma, Non-Hodgkin’s Lymphoma, Sensitivity, Specificity, Performance MetricsReferences
A. M. Badheeb, F. Ahmed, M. Elhadi, N. Alyami, and M. A. Badheeb, “Clinical and Therapeutic Profile of Non-Hodgkin’s Lymphoma: A Retrospective Study From a Najran Oncology Center.,” Cureus, vol. 15, no. 6, p. e40125, Jun. 2023, doi: 10.7759/cureus.40125.
A. Oglat et al., “Characterization and Construction of a Robust and Elastic Wall-Less Flow Phantom for High Pressure Flow Rate Using Doppler Ultrasound Applications,” Nat. Eng. Sci., vol. 3, no. 3, pp. 359–377, Oct. 2018, doi: 10.28978/nesciences.468972.
H. Shaheen, A. Alarab, and M. S Ahmad, “Effectiveness of therapeutic ultrasound and kinesio tape in treatment of tennis elbow,” J. Nov. Physiother. Rehabil., vol. 3, no. 1, pp. 025–033, Apr. 2019, doi: 10.29328/journal.jnpr.1001025.
M. S. Ahmad, O. Makhamrah, and M. Hjouj, “Multimodal Imaging of Hepatocellular Carcinoma Using Dynamic Liver Phantom,” in Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach, vol. 188, no. tourism, IntechOpen, 2022, p. 109632. doi: 10.5772/intechopen.99861.
M. S. Ahmad, N. Suardi, A. Shukri, N. N. Ashikin Nik Ab Razak, O. Makhamrah, and H. Mohammad, “Gelatin-Agar Liver Phantom to Simulate Typical Enhancement Patterns of Hepatocellular Carcinoma for MRI,” Adv. Res. Gastroenterol. Hepatol., vol. 18, no. 05, Jun. 2022, doi: 10.19080/argh.2022.18.555998.
M. S. Ahmad and A. Arab, “Ability of MRI Diagnostic Value to Detect the Evidence of Physiotherapy Outcome Measurements in Dealing with Calf Muscles Tearing,” J. Med. – Clin. Res. Rev., vol. 6, no. 10, pp. 6–11, Oct. 2022, doi: 10.33425/2639-944X.1292.
M. S.Ahmad, S. L. Zeyadeh, R. Odeh, and A. A. Oglat, “Occupational Radiation Dose for Medical Workers at Al-Ahli Hospital in West Bank- Palestine,” J. Nucl. Med. Radiol. Radiat. Ther., vol. 5, no. 1, pp. 1–5, Sep. 2020, doi: 10.24966/NMRR-7419/100017.
O. Makhamrah, M. S. Ahmad, and M. Hjouj, “Evaluation of Liver Phantom for Testing of the Detectability Multimodal for Hepatocellular Carcinoma,” in Proceedings of the 2019 2nd International Conference on Digital Medicine and Image Processing, Nov. 2019, pp. 17–21. doi: 10.1145/3379299.3379307.
M. Ahmad et al., “Chemical characteristics, motivation and strategies in choice of materials used as liver phantom: A literature review,” J. Med. Ultrasound, vol. 28, no. 1, p. 7, 2020, doi: 10.4103/JMU.JMU_4_19.
M. S. Ahmad et al., “A Recent Short Review in Non-Invasive Magnetic Resonance Imaging on Assessment of HCC Stages: MRI Findings and Pathological Diagnosis,” J. Gastroenterol. Hepatol. Res., vol. 9, no. 2, pp. 3113–3123, 2020, doi: 10.17554/j.issn.2224-3992.2020.09.881.
A. A. Oglat, M. Alshipli, M. A. Sayah, and M. S. Ahmad, “Artifacts in Diagnostic Ultrasonography,” J. Vasc. Ultrasound, vol. 44, no. 4, pp. 212–219, Dec. 2020, doi: 10.1177/1544316720923937.
A. Al-Tell, M. Hjouj, M. S.Ahmad, and H. Mohammad, “Justification of Urgent Brain CT Examinations at Medium Size Hospital, Jerusalem,” Atlas J. Biol., pp. 655–660, Dec. 2019, doi: 10.5147/ajb.v0i0.213.
M. S.Ahmad, M. Shareef, M. Wattad, N. Alabdullah, M. D. Abushkadim, and A. A. Oglat, “Evaluation of Exposure Index Values for Conventional Radiology Examinations: Retrospective Study in Governmental Hospitals at West Bank, Palestine,” Atlas J. Biol., pp. 724–729, Dec. 2020, doi: 10.5147/ajb.vi.219.
M. S. Ahmad et al., “Hepatocellular carcinoma liver dynamic phantom for MRI,” Radiat. Phys. Chem., vol. 188, p. 109632, Nov. 2021, doi: 10.1016/j.radphyschem.2021.109632.
K. Hübel, “Lymphoma: New Diagnosis and Current Treatment Strategies.,” J. Clin. Med., vol. 11, no. 6, Mar. 2022, doi: 10.3390/jcm11061701.
X. Jiang, Z. Hu, S. Wang, and Y. Zhang, “Deep Learning for Medical Image-Based Cancer Diagnosis.,” Cancers (Basel)., vol. 15, no. 14, Jul. 2023, doi: 10.3390/cancers15143608.
M. S. Ahmad, B. Rjoub, A. Abuelsamen, and H. Mohammad, “Evaluation of Advanced Medical Imaging Services at Government Hospitals-West Bank,” J. Med. - Clin. Res. Rev., vol. 6, no. 7, pp. 1–7, Jul. 2022, doi: 10.33425/2639-944X.1280.
M. Kmail, M. S. Ahmad, and M. Hjouj, “Evaluating the Accuracy of 128-Section Multi-Detector Computed Tomography (MDCT) in Detecting Coronary Artery Stenosis,” in Proceedings of the 2022 5th International Conference on Digital Medicine and Image Processing, Nov. 2022, pp. 58–62. doi: 10.1145/3576938.3576948.
S. A. Muntaser, M. Rumman, R. A. Malash, A. A. Oglat, and S. Nursakinah, “Evaluation of Positioning Errors for in Routine Chest X- Ray At Beit Jala Governmental Hospital,” Inernational J. Chem. Pharamacy Technol., vol. 3, no. 5, pp. 1–8, 2018.
A. Alarab, R. A. Shameh, and H. M. Shaheen, “Shock Wave Therapy and Ultrasound Therapy plus Exercises for Frozen Shoulder Joint Clients,” Adv. Nurs. Patient Care Int. J. Res., vol. 1, no. 2, 2018, [Online]. Available: https://www.researchgate.net/publication/329949756
A. Oglat et al., “Chemical items used for preparing tissue-mimicking material of wall-less flow phantom for doppler ultrasound imaging,” J. Med. Ultrasound, vol. 26, no. 3, p. 123, 2018, doi: 10.4103/JMU.JMU_13_17.
M. Mohammad, M. S.Ahmad, M. Mudalal, A. Bakry, and T. Arzeqat, “The Radioactive Iodine (I-131) Efficiency for the Treatment of Well-Differentiated Thyroid Cancer,” HSOA J. Nucl. Med. Radiol. Radiat. Ther., vol. 5, no. 25, pp. 5–10, 2020, doi: 10.24966/NMRR-7419/100025.
A. Alarab, R. A. Shameh, and M. S. Ahmad, “Muscle contraction exercise for low back pain,” Hong Kong Physiother. J., vol. 43, no. 01, pp. 53–60, Jun. 2023, doi: 10.1142/S1013702523500075.
A. Mouath D, A. Akram, and A. Muntaser S, “Physical activity and health-related quality of life among physiotherapists in Hebron/West Bank,” J. Nov. Physiother. Rehabil., vol. 4, no. 2, pp. 022–027, Jul. 2020, doi: 10.29328/journal.jnpr.1001033.
Muntaser S. Ahmad et al., “Evaluating the efficacy of breast cancer treatments using PET-CT Imaging,” J. Palest. Ahliya Univ. Res. Stud., vol. 2, no. 1, pp. 158–170, May 2023, doi: 10.59994/pau.2023.1.158.
A. A. Oglat, M. Alshipli, M. A. Sayah, O. F. Farhat, M. S. Ahmad, and A. Abuelsamen, “Fabrication and characterization of epoxy resin-added Rhizophora spp . particleboards as phantom materials for computer tomography (CT) applications,” J. Adhes., vol. 98, no. 8, pp. 1097–1114, Jun. 2022, doi: 10.1080/00218464.2021.1878890.
M. Hjouj and M. S. Ahmad, “Reconstruction From Limited-Angle Projections Based on a Transformation,” in Proceedings of the 2022 5th International Conference on Digital Medicine and Image Processing, Nov. 2022, no. 1, pp. 19–23. doi: 10.1145/3576938.3576942.
M. Hjouj, M. S. Ahmad, and F. Hjouj, “Review and improvement of the linear transformation of images,” in AIP Conference Proceedings, 2023, vol. 060003, no. August, p. 060003. doi: 10.1063/5.0165763.
N. Iyad, M. S.Ahmad, S. G. Alkhatib, and M. Hjouj, “Gadolinium contrast agents- challenges and opportunities of a multidisciplinary approach: Literature review,” Eur. J. Radiol. Open, vol. 11, no. June, p. 100503, Dec. 2023, doi: 10.1016/j.ejro.2023.100503.
A. Alarab et al., “Treatment of Lateral Epicondylitis with Physiotherapy during a Clinical Trial: Comparison of Mobilization Technique and Shock Wave,” J. Med. – Clin. Res. Rev., vol. 6, no. 10, pp. 2–6, Oct. 2022, doi: 10.33425/2639-944X.1293.
O. Makhamrah, M. S. Ahmad, D. Doufish, and H. Mohammad, “Internal Auditory Canal (IAC) and Cerebellopontine Angle (CPA): Comparison between T2-weighted SPACE and 3D-CISS sequences at 1.5T,” Radiat. Phys. Chem., vol. 206, p. 110797, May 2023, doi: 10.1016/j.radphyschem.2023.110797.
M. S. Ahmad, O. Makhamrah, and M. Hjouj, “Multimodal Imaging of Hepatocellular Carcinoma Using Dynamic Liver Phantom,” in Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach, vol. i, no. tourism, IntechOpen, 2022, p. 13. doi: 10.5772/intechopen.99861.
O. Molnar, O. M. Straciuc, S. Mihuțiu, and L. Lazăr, “Impact of PET/CT Imaging with FDG in Locally Advanced Cervical Carcinoma-A Literature Review.,” Curr. Oncol., vol. 31, no. 5, pp. 2508–2526, Apr. 2024, doi: 10.3390/curroncol31050188.
C. C. Ban et al., “Modern heavyweight concrete shielding: Principles, industrial applications and future challenges; review,” J. Build. Eng., vol. 39, no. March 2022, p. 102290, Jul. 2021, doi: 10.1016/j.jobe.2021.102290.
M. S. Ahmad et al., “Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality Imaging,” Eur. J. Radiol. Open, vol. 7, no. September, p. 100257, 2020, doi: 10.1016/j.ejro.2020.100257.
M. S. Ahmad, O. Makhamrah, N. Suardi, A. Shukri, N. N. A. N. A. Razak, and H. Mohammad, “Agarose and Wax Tissue-Mimicking Phantom for Dynamic Magnetic Resonance Imaging of the Liver,” J. Med. - Clin. Res. Rev., vol. 5, no. 12, Dec. 2021, doi: 10.33425/2639-944X.1250.
M. S. Ahmad et al., “Current Status Regarding Tumour Progression, Surveillance, Diagnosis, Staging, and Treatment Of HCC: A Literature Review,” J. Gastroenterol. Hepatol. Res., vol. 8, no. 2, pp. 2841–2852, 2019, doi: 10.17554/j.issn.2224-3992.2019.07.814.
M. S. Ahmad and H. Mohammad, “Statistical calculation of beta radiotherapy dose using I-131: analysis and simulation method.,” J. Phys. Conf. Ser., vol. 2701, no. 1, p. 012026, Feb. 2024, doi: 10.1088/1742-6596/2701/1/012026.
R. K. Alqam, M. S. Ahmad, and H. Mohammad, “Signal Quantification of Intravenous Contrast Agents Enhancement from Biphase Liver CT Scan Procedures,” J. Phys. Conf. Ser., vol. 2701, no. 1, p. 012064, Feb. 2024, doi: 10.1088/1742-6596/2701/1/012064.
A. Nazzal, M. S. Ahmad, and H. Mohammad, “Justification of Urgent Brain CT scans at Palestinian Government Hospitals,” J. Phys. Conf. Ser., vol. 2701, no. 1, p. 012065, Feb. 2024, doi: 10.1088/1742-6596/2701/1/012065.
M. Rumman, M. S.Ahmad, H. Mohammad, A. A. Oglat, N. Suardi, and H. Altalahmah, “An Assessment of Senior and Junior Medical Imaging Student’s Familiarity With Correct Radiographic Evaluation Criteria and Clinical Training Efficiency,” Int. J. Chem. Pharm. Technol., no. August, 2018.
M. S. Ahmad, A. J. Rizeq, I. A. Abu Saleh, and D. H. Bshara, “Assessing Radiographic Technologist Precision and its Influence on Patient Exposure Index: Analytical Retrospective Study in a Small Palestinian Government Hospital,” J. Palest. Ahliya Univ. Res. Stud., vol. 1, no. 2, pp. 76–85, Dec. 2022, doi: 10.59994/pau.2022.2.76.
M. Shatat and M. S. Ahmad, “The Role of Cardiac MRI and Echocardiography in the Treatment of Cardiac Disorders in the Palestinian Health System,” pp. 130–135, doi: https://doi.org/10.1145/3637684.3637713.
M. E. Kruk et al., “High-quality health systems in the Sustainable Development Goals era: time for a revolution.,” Lancet. Glob. Heal., vol. 6, no. 11, pp. e1196–e1252, Nov. 2018, doi: 10.1016/S2214-109X(18)30386-3.
N. Horesh and N. A. Horowitz, “Does Gender Matter in Non-Hodgkin Lymphoma? Differences in Epidemiology, Clinical Behavior, and Therapy,” Rambam Maimonides Med. J., vol. 5, no. 4, p. e0038, Oct. 2014, doi: 10.5041/RMMJ.10172.
B. J. Fueger, K. Yeom, J. Czernin, J. W. Sayre, M. E. Phelps, and M. S. Allen-Auerbach, “Comparison of CT, PET, and PET/CT for staging of patients with indolent non-Hodgkin’s lymphoma.,” Mol. imaging Biol., vol. 11, no. 4, pp. 269–274, 2009, doi: 10.1007/s11307-009-0200-9.
S. S. Sunny, R. Oommen, J. Hephzibah, N. Shanthly, D. Mathew, and A. Eapen, “Analysis of discordant PET and CT findings in 18F-FDG PET-CT scans in the management of oncology patients.,” Indian J. Cancer, Nov. 2023, doi: 10.4103/ijc.IJC_1202_20.
D. K. Osmonov, D. Heimann, I. Janßen, A. Aksenov, A. Kalz, and K. P. Juenemann, “Sensitivity and specificity of PET/CT regarding the detection of lymph node metastases in prostate cancer recurrence.,” Springerplus, vol. 3, p. 340, 2014, doi: 10.1186/2193-1801-3-340.
J. Kasem, U. Wazir, and K. Mokbel, “Sensitivity, Specificity and the Diagnostic Accuracy of PET/CT for Axillary Staging in Patients With Stage I-III Cancer: A Systematic Review of The Literature.,” In Vivo, vol. 35, no. 1, pp. 23–30, 2021, doi: 10.21873/invivo.12228.
R. Boellaard et al., “FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0,” Eur. J. Nucl. Med. Mol. Imaging, vol. 42, no. 2, pp. 328–354, Feb. 2015, doi: 10.1007/s00259-014-2961-x.
S. Hussain et al., “Modern Diagnostic Imaging Technique Applications and Risk Factors in the Medical Field: A Review.,” Biomed Res. Int., vol. 2022, p. 5164970, 2022, doi: 10.1155/2022/5164970.